IONSIonis Pharmaceuticals, Inc.
Is it safe?
Forensics clean, with a caveat: a safe balance sheet and insiders buying, but heavy debt (CCC) and big price swings.
Financially healthy, low distress risk Altman Z-score, a bankruptcy-risk model from five balance-sheet ratios.
Mixed fundamental signals Piotroski F-score, nine pass/fail tests of year-over-year financial health across profitability, balance sheet and efficiency. 7 to 9 is strong, 0 to 3 weak.
Insiders were net buyers (+$997K, 90 days to Oct 22, 2026). SEC Form 4 filings: officers and directors must report their own trades within two business days.
Debt against weak or negative operating profit. A rule of thumb on leverage, not a credit rating.
Large price swings, high volatility. Worst drawdown -70% · now 50% below its 52-week high.
Unless marked, from SEC EDGAR, as of Dec 31, 2025.
Against the whole market›
Percentile against every name Ryufin tracks. Higher is better; the tick marks the middle of the market. Context, not one of the checks above.
Where this answer is blind. Altman sits structurally low for utilities and pipelines; Beneish runs high for fast growers, since sales growth alone lifts it; banks and REITs are excluded.
Can IONS take a bad year?
The deepest fall in IONS's price history on file is −70%; it is 50% below its high today.
Altman Z-score · distress below 1.8 · safe above 3 · distress zone, the model puts this in the bankruptcy range
- Cash runway
- 2.6 years
Cash runway · burning $140M a quarter at the current rate
- Annualised volatility
- 48%
Annualised volatility · S&P 500 16% · about 3 times the market's own swing
- Worst drawdown on file
- −70%
Worst drawdown on file · −50% today
Details›
- Cash and short-term investments
- $1.49B
- EBITDA, trailing twelve months
- −$582M
- Operating profit, trailing twelve months
- −$594M
- Annualised volatilitytwo years of daily moves
- 48%
- Worst drawdown on file
- −70%
- Below its 52-week high
- 50%
Balance sheet from SEC filings; drawdown and volatility from end-of-day closes; Altman Z from the filed statements.
The balance sheet
What it owes against what it owns, and how close that comes to trouble.
How far can it fall?
How much the price moves, how deep and how long its falls have run, and what each unit of risk has paid.