PTGXProtagonist Therapeutics, Inc.

$138.40+83% 1Y

What is the market doing?

Mixed

No clear lean: nothing decisive, though heavily shorted (+14% of shares).

1 to watch, 2 neutral
TrendRangeboundderived · Oct 23, 2026

Choppy, but holding above its 200-day average. Price is +21% vs its 200-day average.

Insider conviction−$41.4M (90 days to Oct 22, 2026)SEC EDGAR · Oct 22, 2026

Insiders were net sellers over the 90 days ending Oct 22, 2026; selling is often routine (taxes, diversification).

Short interest14% of sharesFINRA · Sep 30, 2026

Heavily shorted, settled Sep 30, 2026, more than a week of normal trading to cover, a crowded exit.

Against the whole market›

Percentile against every name Ryufin tracks. Higher is better; the tick marks the middle of the market. Context, not one of the checks above.

1-year returntop 7% of the market
vs 200-day avgbetter than 87% of the market

Where this answer is blind. Insider selling is often routine (taxes, diversification); only cluster buying is a strong tell.

How PTGX is trading

Protagonist Therapeutics, Inc. is +83% over the past year while the S&P 500 is +16%: 67 points ahead of the market.

+83%

1-year return · S&P 500 +16%

vs 200-day average
+21%

vs 200-day average · a clear uptrend

RSI (14)
47

RSI (14) · neutral

Below its 52-week high
13%

Below its 52-week high

Oct 15, 2024$33.03 – $158.64 · dashed line: 200-day averageOct 23, 2026
Details›
Last close2026-10-23
$138.40
1 monthS&P 500 −0.94%
+0.82%
1 yearS&P 500 +16%
+83%
5 yearsS&P 500 +86%
+291%
vs 50-day average$144.26
−4.1%
52-week high
$158.63
52-week low
$73.50
Annualised volatility
57%
Insider selling, net, 6 monthsForms 3/4/5 to 2026-10-22
$5.9M
Calendar-year price return
YearReturn
2026 (year to date)+58%
2025+126%
2024+68%
2023+110%
2022−68%
2021+70%
2020+186%
2019+4.8%
2018−68%
2017−5.4%
Average return by calendar month, 2016–2026
MonthYearsPositiveAverage
Jan106 of 10+3.1%
Feb105 of 10+0.49%
Mar105 of 10+7.8%
Apr102 of 10−12%
May107 of 10+19%
Jun108 of 10+11%
Jul106 of 10+1.4%
Aug108 of 10+15%
Sep115 of 11+0.06%
Oct114 of 11+3.4%
Nov106 of 10+7.7%
Dec105 of 10+1.4%

End-of-day closes from IEX; the S&P 500 comparison uses SPY over the same window. Prices are a reference point, not a basis for trading decisions.

Where the price stands

Its trend against the 50-day and 200-day averages, and the levels it keeps coming back to.

What it has returned

With dividends, year by year, month by month, and by calendar month on average.

On our screens:Most shorted stocks