AZN vs MRK

AstraZeneca PLC and Merck & Co., both Healthcare

AstraZeneca PLC is the larger company at $288B against $281B. On trailing earnings AZN is the cheaper of the two at a P/E of 26.4 against 117.8, a gap that is only a bargain if the two are growing at similar rates. Over the past year MRK returned +82% against +2.2% for AZN. Ryufin's sector-relative Smart Score puts AZN ahead, 9/10 against 8/10.

AstraZeneca PLC and Merck & Co.compared on valuation, return and Ryufin’s Smart Score
FigureAZNMRK
Last close$160$148
Market cap$288B$281B
Trailing P/Elower is cheaper for the same earnings, not automatically better26.4117.8
Dividend yieldn/a2.2%
1-year return+2.2%+82%
5-year return+57%+131%
Ryufin Smart Scoresector-relative, 1–109/108/10

Figures from SEC filings and end-of-day closes. Highlighting marks the higher or lower number, which is not the same as the better investment, a low P/E can be a warning and a high one can be deserved.

AstraZeneca PLC

Revenue of $31B in H2 2025, net income $4.9B.

Merck & Co.

Revenue of $17B in Q2 2026, net income null. Its largest reported line is Keytruda, 49% of the disclosed total.

Open these two in the interactive comparison to add more names, change the period or see the correlation.